Publications

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	Gradwell MA, Ozeri-Engelhard N, Eisdorfer JT, Laflamme OD, Gonzalez M, Upadhyay A, Medlock L, Shrier T, Patel KR, Aoki A, Gandhi M, Zadeh GA, Oputa O, Thackray JK, Ricci M, George AJ, Yusuf N, Keating J, Imtiaz Z, Alomary SA, Bohic M, Haas M, Hernandez Y, Prescott SA, Akay T, Abraira VE. Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn. Neuron 2024, https://doi.org/10.1016/j.neuron.2024.01.027.
	Sagalajev B, Zhang T, Abdollahi N, Yousefpour N, Medlock L, Al-Basha D, Ribeiro-da-Silva A, Esteller R, Ratté S, Prescott SA. Absence of paresthesia during during high-rate spinal cord stimulation reveals importance of synchrony for sensations evoked by electrical stimulation. Neuron, 2023 Nov 9:S0896-6273(23)00802-4. Also see the accompanying Preview article , "Does high-frequency stimulation of sensory axons break the causal link between pain relief and paresthesia?", by ER Rogers, SF Lempka, and Marco Capogrosso.
	Dedek C, Azadgoleh MA, Prescott SA. Reproducible and fully automated testing of nocifensive behavior in mice. Cell Rep Methods 2023, Cell Reports Methods 3, 100650. Also see the accompanying Preview article , "An automaton for preclinical pain testing", by RD Graham and MC Creed.
	Xie YF, Yang J, Ratté S, Prescott SA. Equivalent excitability through different sodium channel subtypes and implications for analgesia by subtype-selective drugs eLife 2023; https://doi.org/10.7554/eLife.90960.1
	Yang J, Prescott SA. Homeostatic regulation of neuronal function: importance of degeneracy and pleiotropy. Front Cell Neurosci 2023; 17: 1184563.
	Rezaei MR, Fard RS, Popovic MR, Prescott SA, Lankarany M. Synchrony-Division Neural Multiplexing: An Encoding Model. Entropy (Basel) 2023; 25(4):589.
	Kamaleddin MA, Shifman A, Abdollahi N, Sigal DMW, Ratté S, Prescott SA. Physiological noise facilitates multiplexed coding of vibrotactile-like signals in somatosensory cortex PNAS 2022; 119: e2118163119.
	Yang J, Shakil H, Ratté S, Prescott SA. Minimal requirements for a neuron to co-regulate many properties and the implications for ion channel correlations and robustness. eLife 2022;11:e72875.
	Medlock L, Sekiguchi K, Hong S, Dura-Bernal S, Lytton WW, Prescott SA Multiscale computer model of the spinal dorsal horn reveals changes in network processing associated with chronic pain J Neurosci 2022; 42(15):3133–3149. Also see the accompanying Research Spotlight.
	Tian J, Yang J, Joslin WC, Flockerzi V, Prescott SA, Birnbaumer L, Zhu MX. TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect Gq/11-Gi/o coincidence signals of variable strengths. PNAS 2022; 119: e2120870119.
	Kamaleddin MA, Abdollahi N, Ratté, Prescott SA. Spike initiation properties in the axon support high-fidelity signal transmission BioRxiv 2021 https://www.biorxiv.org/content/10.1101/2021.12.13.472435v1
	Lee KY, Ratté S, Prescott SA. Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn. eLife 2019; 8:e49753.
	Hildebrandt MR, Reuter MS, Wei W, Tayebi N, Liu J, Sharmin S, Mulder J, Lesperance LS, Brauer PM, Mok RSF, Kinnear C, Piekna A, Romm A, Howe J, Pasceri P, Meng G, Rozycki M, Rodrigues DC, Martinez EC, Szego MJ, Zúñiga-Pflücker JC, Anderson MK, Prescott SA, Rosenblum ND, Kamath BM, Mital S, Scherer SW, Ellis J. Precision Health Resource of Control iPSC Lines for Versatile Multilineage Differentiation. Stem Cell Reports 2019; 13(6):1126-1141.
	Al-Basha D, Prescott SA. Intermittent failure of spike propagation in primary afferent neurons during tactile stimulation. J Neurosci 2019;39(50):9927-9939.
	Mapplebeck JCS, Lorenzo LE, Lee KY, Gauthier C, Muley MM, De Koninck Y, Prescott SA, Salter MW. Chloride dysregulation through downregulation of KCC2 mediates neuropathic pain in both sexes. Cell Rep 2019; 28: 590-596.
	Kemaladewi DU, Bassi PS, Erwood S, Al-Basha D, Gawlik KI, Lindsay K, Hyatt E, Kember R, Place KM, Marks RM, Durbeej M, Prescott SA, Ivakine EA, Cohn RD. A mutation-independent approach for muscular dystrophy via upregulation of a modifier gene. Nature 2019; 572: 125-130.
	Lankarany M, Al-Basha D, Ratté S, Prescott SA. Differentially synchronized spiking enables multiplexed neural coding. PNAS 2019; 116:10097-10102.
	FallahRad M, Zannou AL, Khadka N, Prescott SA, Ratté S, Zhang T, Esteller R, Hershey B, Bikson M. Electrophysiology equipment for reliable study of kHz electrical stimulation. J Physiol 2019; 597:2131-2137.
	Mouchbahani-Constance S, Lesperance LS, Petitjean H, Davidova A, Macpherson A, Prescott SA, Sharif-Naeini R. Lionfish venom elicits pain predominantly through the activation of nonpeptidergic noiciceptors. Pain 2018; 159: 2255-2266.
	Mousseau M, Burma NE, Lee KY, Leduc-Pessah H, Kwok CHT, Reid AR, O'Brien M, Sagalajev B, Stratton JA, Patrick N, Stemkowski PL, Biernaskie J, Zamponi GW, Salo P, McDougall JJ, Prescott SA, Matyas JR, Trang T. Microglial pannexin-1 channel activation is a spinal determinant of joint pain. Sci Adv. 2018; 4(8):eaas9846.
	Wang F, Bélanger E, Côté SL, Desrosiers P, Prescott SA, Côté DC, De Koninck Y. Sensory afferents use different coding strategies for heat and cold. Cell Reports 2018; 23: 2001–2013.
	Takkala P, Prescott SA. Using dynamic clamp to quantify pathological changes in the excitability of primary somatosensory neurons. J Physiol 2018; 596:2209-2227.
	Ratté S, Karnup S, Prescott SA. Nonlinear relationship between spike-dependent calcium influx and TRPC channel activation enables robust persistent spiking in neurons of the anterior cingulate cortex. J Neurosci 2018; 38(7):1788 –1801.
	Balachandar A and Prescott SA. Origin of heterogeneous spiking patterns from continuously distributed ion channel densities: a computational study in spinal dorsal horn neurons. J Physiol 2018; 596: 1681-1697. Also see the accompanying Perspective article , "Moving Functional Classification of Dorsal Horn Neurons from Art to Science", by MA Tadros, BA Graham, and RJ Callister.
	Lesperance LS, Lankarany M, Zhang TC, Esteller R, Ratté S, Prescott SA. Artifactual hyperpolarization during extracellular electrical stimulation: Proposed mechanism of high-rate neuromodulation disproved. Brain Stimulation 2018; 11(3):582-591.
	Bells S, Lefebvre J, Prescott SA, Dockstader C, Bouffet E, Skocic J, Laughlin S, Mabbott DJ. Changes in White Matter Microstructure Impact Cognition by Disrupting the Ability of Neural Assemblies to Synchronize. J Neurosci 2017; 37: 8227-8238.
	Takkala P, Zhu Y, Prescott SA. Combined changes in chloride regulation and neuronal excitability enable primary afferent depolarization to elicit spiking without compromising its inhibitory effects. PLoS Comput Biol 2016; e1005215.
	Doyon N, Vinay L, Prescott SA, De Koninck Y. Chloride regulation: A dynamic equilibrium crucial for synaptic inhibition. Neuron 2016; 89: 1157-1172.
	Doyon N, Prescott SA, De Koninck Y. Mild KCC2 hypofunction causes inconspicuous chloride dysregulation that degrades neural coding. Front Cell Neurosci 2016; 9:516.
	Ratté S, Prescott SA. Afferent hyperexcitability in neuropathic pain and the inconvenient truth about its degeneracy. Curr Opin Neurobiol 2016; 36:31–37.
	Khubieh A, Ratté S, Lankarany M, Prescott SA. Regulation of cortical dynamic range by background synaptic noise and feedforward inhibition. Cerebral Cortex 2016; 26: 3357-69.
	Coggan JS, Bittner S, Stiefel KM, Meuth SG, Prescott SA. Physiological Dynamics in Demyelinating Diseases: Unravelling Complex Relationships through Computer Modeling. Int J Molec Sci 2015; 16(9:, 21215-21236.
	Lee KY, Prescott SA. Chloride dysregulation and inhibitory receptor blockade yield equivalent disinhibition of spinal neurons yet are differentially reversed by carbonic anhydrase blockade. Pain 2015; 156: 2431-2437.
	Coggan JS, Sejnowski TJ, Prescott SA. Cooperativity between remote sites of ectopic spiking allows afterdischarge to be initiated and maintained at different locations. J Comput Neurosci 2015; 39: 17-28.
	Price TJ, Prescott SA. Inhibitory regulation of the pain gate and how its failure cause pathological pain. Pain 2015; 156: 789-792.
	Ratté S, Lankarany M, Rho YA, Patterson A, Prescott SA. Subthreshold membrane currents confer distinct tuning properties that enable neurons to encode the integral or derivative of their input. Front Cell Neurosci 2015; 8: 452.
	Zhu Y, Feng B, Schwartz ES, Gebhart GF, Prescott SA. Novel method to assess axonal excitability using channelrhodopsin-based photoactivation. J Neurophysiol. 2015; 113: jn.00982.2014.
	Ratté S, Zhu Y, Lee KY, Prescott SA. Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain. Elife. 2014 Apr 18;3:e02370. Also see the accompanying Insight article , "The pros and cons of degeneracy", by J Goaillard and MA Dufour, and eLife Podcast with Christopher Smith.
	Prescott SA, Ma Q, De Koninck Y. Normal and abnormal coding of somatosensory stimuli causing pain. Nat Neurosci. 2014 Feb;17(2):183-91.
	Ratté S, Hong S, De Schutter E, Prescott SA. Impact of neuronal properties on network coding: roles of spike initiation dynamics and robust synchrony transfer. Neuron. 2013 Jun 5;78(5):758-72. doi: 10.1016/j.neuron.2013.05.030.
	Prescott SA, Ratté S Pain processing by spinal microcircuits: afferent combinatorics. Curr Opin Neurobiol. 2012 Aug;22(4):631-9.
	Rho Y-A &Prescott SA. Identification of molecular pathologies sufficient to cause neuropathic excitability in primary somatosensory afferents using dynamical systems theory. PLoS Comput Biol 2012; 8: e1002524.
	Hong S, Ratté S, Prescott SA & De Schutter E. Single neuron firing properties impact correlation-based coding. J Neurosci 2012; 32: 1413-1428.
	Ratté S & Prescott SA. ClC-2 channels regulate neuronal excitability, not intracellular chloride levels. J. Neurosci. 2011; 31: 15838-15843.
	Coggan JS, Ocker GK, Sejnowski TJ & Prescott SA. Explaining pathological changes in axonal excitability through dynamical analysis of conductance-based models. J. Neural. Eng. 2011; 8: 065002.
	Doyon N, Prescott SA, Castonguay, Godin AG, Kroger H & De Koninck Y. Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis. PLoS Comput. Biol. 2011; 7: e1002149.
	Coggan JS, Prescott SA, Bartol JA & Sejnowski TJ. Imbalance of ionic conductances contributes to diverse symptoms of demyelination. Proc. Natl. Acad. Sci. USA 2010; 107: 20602-20609.
	Price TJ, Cervero F, Gold MS, Hammond D, Prescott SA. Chloride regulation in the pain pathway. Brain Res. Rev. 2009; 60: 149-170.
	Prescott SA & Sejnowski TJ. Spike-rate coding and spike-time coding are affected oppositely by different adaptation mechanisms. J. Neurosci. 2008; 28: 13649-13661.
	Prescott SA, Ratté S, De Koninck Y, Sejnowski TJ. Pyramidal neurons switch from integrators in vitro to resonators under in vivo-like conditions. J. Neurophysiol. 2008; 100: 3030-3042.
	Prescott SA, De Koninck Y, Sejnowski TJ. Biophysical basis for three distinct dynamical mechanisms of action potential initiation. PLoS Comput. Biol. 2008; 4: e1000198.
	Ratté S, Prescott SA, Collinge J, Jefferys JGR. Mouse model of variant CJD exhibits prion strain-specific changes in NMDA receptor-dependent excitation causing bursts in the hippocampus. Neurobiol. Dis. 2008; 32: 96-104.
	Prescott SA, Sejnowski TJ, De Koninck Y. Reduction of anion reversal potential subverts the inhibitory control of firing rate in spinal lamina I neurons: towards a biophysical basis for neuropathic pain. Mol. Pain 2006; 2: 32.
	Prescott SA, Ratté S, De Koninck Y, Sejnowski TJ. Nonlinear interaction between shunting and adaptation controls a switch between integration and coincidence detection in pyramidal neurons. J. Neurosci. 2006; 26: 9084-9097. Rated “must read” in Faculty of 1000 Biology.
	Prescott SA, De Koninck Y. 2005. Integration time in a subset of spinal lamina I neurons is lengthened by sodium and calcium currents acting synergistically to prolong subthreshold depolarization. J. Neurosci. 2005; 25: 4743-4754.
	Coull JAM, Boudreau D, Bachand K, Prescott SA, Nault F, Sik A, De Koninck P, De Koninck Y. Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature 2003; 424: 938-942.
	Prescott SA, De Koninck Y. Gain control of firing rate by shunting inhibition: roles of synaptic noise and dendritic saturation. Proc. Natl. Acad. Sci. USA 2003: 100; 2076-2081.
	Prescott SA, De Koninck Y. Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat. J. Physiol. 2002: 539; 817-836.

	Book Chapters
	Prescott SA, Ratté S. Somatosensation and pain. Chapter 11 in: Conn's Translational Neuroscience. 2017. Conn (ed). Elsevier. **Please contact us to request a copy
	Prescott SA Synaptic inhibition and disinhibition in the spinal dorsal horn. In: Molecular Biology of Pain, Progress in Molecular and Translational Science. 2015. Price TJ, Dussor G (eds). Elsevier.
	Prescott SA Chloride channels. Chapter 226 in: Encyclopedia of Computational Neuroscience. 2014. Jaeger D, Jung R (eds). Springer.
	Prescott SA Excitability: Hodgkin’s classes I, II, and III. Chapter 151 in: Encyclopedia of Computational Neuroscience. 2014. Jaeger D, Jung R (eds). Springer.
	Prescott SA Pathological changes in peripheral nerve excitability. Chapter 748 in: Encyclopedia of Computational Neuroscience. 2014. Jaeger D, Jung R (eds). Springer.
	Prescott SA Pain processing pathway models. Chapter 250 in: Encyclopedia of Computational Neuroscience. 2014. Jaeger D, Jung R (eds). Springer. 2014.
	Prescott SA & De Koninck Y. Impact of background synaptic activity on neuronal response properties revealed by stepwise replication of in vivo-like conditions in vitro. In: The Dynamic Clamp: From Principles to Applications. Destexhe A & Bal T (eds). Springer. 2009.

Publications

Book Chapters